Annexin A2

Annexin A2
PDB rendering based on 1w7b.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1W7B, 1XJL, 2HYU, 2HYV, 2HYW, 4DRW, 4FTG, 4HRH
Identifiers
Symbols	ANXA2 ; ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2; LPC2D; P36; PAP-IV
External IDs	OMIM: 151740 MGI: 88246 HomoloGene: 20857 ChEMBL: 1764938 GeneCards: ANXA2 Gene
Gene ontology Molecular function • protease binding • calcium ion binding • protein binding • calcium-dependent phospholipid binding • phosphatidylinositol-4,5-bisphosphate binding • cytoskeletal protein binding • Rab GTPase binding • phospholipase A2 inhibitor activity • receptor activator activity • S100 protein binding • poly(A) RNA binding • calcium-dependent protein binding Cellular component • ruffle • basement membrane • extracellular space • nucleus • lysosomal membrane • endosome • early endosome • lipid particle • plasma membrane • cell cortex • cell surface • membrane • basolateral plasma membrane • extrinsic component of plasma membrane • midbody • extracellular matrix • late endosome membrane • vesicle • myelin sheath adaxonal region • sarcolemma • melanosome • Schmidt-Lanterman incisure • macropinosome • membrane raft • perinuclear region of cytoplasm • extracellular exosome • PCSK9-AnxA2 complex Biological process • angiogenesis • membrane raft assembly • positive regulation of protein phosphorylation • negative regulation of receptor internalization • membrane budding • body fluid secretion • collagen fibril organization • positive regulation of vesicle fusion • negative regulation of low-density lipoprotein particle receptor catabolic process • osteoclast development • fibrinolysis • negative regulation of catalytic activity • positive regulation of fibroblast proliferation • positive regulation of binding • protein heterotetramerization • protein targeting to plasma membrane • negative regulation of receptor binding • positive regulation of receptor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	302	12306
Ensembl	ENSG00000182718	ENSMUSG00000032231
UniProt	P07355	P07356
RefSeq (mRNA)	NM_001002857	NM_007585
RefSeq (protein)	NP_001002857	NP_031611
Location (UCSC)	Chr 15: 60.35 – 60.4 Mb	Chr 9: 69.45 – 69.49 Mb
PubMed search	[1]	[2]

Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene.

Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells), linkage of membrane-associated protein complexes to the actin cytoskeleton, endocytosis, fibrinolysis, ion channel formation, and cell matrix interactions. It is a calcium-dependent phospholipid-binding protein whose function is to help organize exocytosis of intracellular proteins to the extracellular domain. Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body.

Gene

The ANXA2 gene, located at 15q22.2, has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Function

This protein is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption.

Annexin A2 has been proposed to function inside the cell in sorting of endosomes and outside the cell in anticoagulant reactions.

Interactions

Annexin A2 has been shown to interact with Prohibitin, CEACAM1, S100A10, PCNA and complement Factor H

See also

• Annexin

External links

• Annexin A2 at the US National Library of Medicine Medical Subject Headings (MeSH)