Platelet alpha-granule
| Alpha granule | |
|---|---|
| Details | |
| Latin | granulum alpha |
| Identifiers | |
| Code | TH H2.00.04.1.03005 |
| TA | Lua error in Module:Wikidata at line 744: attempt to index field 'wikibase' (a nil value). |
| TH | {{#property:P1694}} |
| TE | {{#property:P1693}} |
| FMA | {{#property:P1402}} |
| Anatomical terminology
[[[d:Lua error in Module:Wikidata at line 863: attempt to index field 'wikibase' (a nil value).|edit on Wikidata]]]
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In platelets, the term "alpha granules" is used to describe granules containing several growth factors.[1]
Contents of alpha-granules
Contents include insulin-like growth factor 1, platelet-derived growth factors, TGFβ, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V,[2] and von Willebrand factor).[3]
The alpha granules express the adhesion molecule P-selectin[4] and CD63.[5] These are transferred to the membrane after synthesis.
The other type of granules within platelets are called dense granules.
Clinical significance
A deficiency of alpha granules is known as gray platelet syndrome.
See also
References
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- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://www.bloodjournal.org/content/118/5/1190
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