KLRA1
Lua error in Module:Infobox at line 235: malformed pattern (missing ']'). Lua error in Module:Infobox at line 235: malformed pattern (missing ']'). Ly-49 receptors or killer cell lectin-like receptor subfamily A (KLRA), are a class of natural killer cell receptor.[1][2] Ly-49 proteins are a diverse set of C-type lectins that are expressed on NK cells in some mammals, including rodents but not humans. Their primary function is to bind host MHC class I as a mechanism of self/health recognition. Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. In the case of cancer or virally infected cells, MHC-I will often be downregulated in order to limit cytotoxic T cell mediated killing of the cell, whereby NK cells will lack Ly-49 inhibitory signal and be able to kill infected or cancerous target cells.
The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD).[3][4]
References
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<references />, or <references group="..." />External links
- Ly-49 antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
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