Keratocystic odontogenic tumour

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Keratocystic odontogenic tumour
Keratocystic odontogenic tumour - 2 - very high mag.jpg
Micrograph of a keratocystic odontogenic tumour. H&E stain.
Classification and external resources
Specialty Lua error in Module:Wikidata at line 446: attempt to index field 'wikibase' (a nil value).
ICD-10 D16.4 (Maxilla); D16.5 (mandible)
ICD-9-CM 213.0-213.1
Patient UK Keratocystic odontogenic tumour
[[[d:Lua error in Module:Wikidata at line 863: attempt to index field 'wikibase' (a nil value).|edit on Wikidata]]]

A keratocystic odontogenic tumour (also keratocystic odontogenic tumor, KCOT)[1] is a rare and benign but locally aggressive developmental cystic neoplasm. It most often affects the posterior mandible.

It used to be called odontogenic keratocyst (OKC).[1][2]

Diagnosis

Classic look to a keratocyctic odontogenic tumor in the right mandible in the place of a former wisdom tooth. Unicystic lesion growing along the bone.

The definitive diagnosis is by histologic analysis, i.e. excision and examination under the microscope.

Under the microscope, KCOTs vaguely resemble keratinized squamous epithelium;[3] however, they lack rete ridges and often have an artifactual separation from their basement membrane.

Etiology

KCOTs are thought to arise from the dental lamina and associated with impacted teeth. Multiple odontogenic keratocysts are a feature of nevoid basal cell carcinoma syndrome. Odotogenic Keratocysts are derived from the Remnants of the Dental Lamina.

Genetics

Sporadic (non-syndromic) and syndromic KCOTs are associated with mutations in the gene PTCH, which is part of the Hedgehog signaling pathway.[1][4]

Symptoms

Swelling is the most common presenting complaint; however, KCOTs may be asymptomatic and found incidentally on dental X-rays.[5]

Differential diagnosis

Radiologically

Histologically

Malignant transformation

Malignant transformation to squamous cell carcinoma may occur, but is unusual.[6]

Treatment

Massive keratocystic odontogenic tumour with impacted wisdom teeth superficial to lesion

As the entity is quite rare, opinions among experts about how to treat KCOTs differ.

Treatment options:[1]

  • Wide (local) surgical excision.
  • Marsupialization - the surgical opening of the (KCOT) cavity and a creation of a marsupial-like pouch, so that the cavity is in contact with the outside for an extended period, e.g. three months.
  • Curettage (simple excision & scrape-out of cavity).
  • Peripheral ostectomy after curettage and/or enucleation.
  • Simple excision.
  • Carnoy's solution - usually used in conjunction with excision.
  • Enucleation and cryotherapy [7]

Additional images

  • Intermed. mag.

  • High mag.

  • Intermed. mag.

References

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Additional reading

  • Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.


  1. ↑ 1.0 1.1 1.2 1.3 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Thompson LDR. Head and neck pathology - (Foundations in diagnostic pathology). Goldblum JR, Ed.. Churchill Livingstone. 2006. ISBN 0-443-06960-3.
  4. ↑ PATCHED, DROSOPHILA, HOMOLOG OF, 1; PTCH1. OMIM. URL: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601309. Accessed on: December 25, 2008.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.[dead link]
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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