ALG1

ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
Identifiers
Symbols	ALG1 ; CDG1K; HMAT1; HMT-1; HMT1; MT-1; Mat-1; hMat-1
External IDs	OMIM: 605907 MGI: 2384774 HomoloGene: 5387 GeneCards: ALG1 Gene
EC number	2.4.1.142
Gene ontology Molecular function • mannosyltransferase activity • chitobiosyldiphosphodolichol beta-mannosyltransferase activity Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral component of membrane Biological process • protein glycosylation • dolichol-linked oligosaccharide biosynthetic process • lipopolysaccharide biosynthetic process • protein N-linked glycosylation via asparagine • post-translational protein modification • cellular protein metabolic process • mannosylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56052	208211
Ensembl	ENSG00000033011	ENSMUSG00000039427
UniProt	Q9BT22	Q921Q3
RefSeq (mRNA)	NM_019109	NM_145362
RefSeq (protein)	NP_061982	NP_663337
Location (UCSC)	Chr 16: 5.03 – 5.09 Mb	Chr 16: 5.23 – 5.24 Mb
PubMed search	[1]	[2]

Chitobiosyldiphosphodolichol beta-mannosyltransferase is an enzyme that is encoded by the ALG1 gene whose structure and function has been conserved from yeast to man.

Function

The biosynthesis of lipid-linked oligosaccharides is highly conserved among eukaryotes and is catalyzed by 14 glycosyltransferases in an ordered stepwise manner. The Alg1 mannosyltransferase I (MT I) catalyzes the first mannosylation step in this process.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview