ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9
250px PDB rendering based on 2dfk.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2YSQ
Identifiers
Symbols	ARHGEF9 ; COLLYBISTIN; EIEE8; HPEM-2; PEM-2; PEM2
External IDs	OMIM: 300429 MGI: 2442233 HomoloGene: 9053 GeneCards: ARHGEF9 Gene
Gene ontology Molecular function • Rho guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol Biological process • small GTPase mediated signal transduction • synaptic transmission • ion transmembrane transport • regulation of Rho protein signal transduction • positive regulation of apoptotic process • positive regulation of GTPase activity • neurotrophin TRK receptor signaling pathway • regulation of small GTPase mediated signal transduction • transmembrane transport • apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE ARHGEF9 203263 s at tn.png
File:PBB GE ARHGEF9 203264 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23229	236915
Ensembl	ENSG00000131089	ENSMUSG00000025656
UniProt	O43307	Q3UTH8
RefSeq (mRNA)	NM_001173479	NM_001033329
RefSeq (protein)	NP_001166950	NP_001028501
Location (UCSC)	Chr X: 63.63 – 63.81 Mb	Chr X: 95.05 – 95.2 Mb
PubMed search	[1]	[2]

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.

Function

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM]

Interactions

ARHGEF9 has been shown to interact with GPHN and SMURF1.