Acetyl hexapeptide-3

Acetyl hexapeptide-3

Stereo, skeletal formula of acetyl hexapeptide-3
Names
Other names (6S,9S,12S,15S,18S,21S)-21-Acetamido-1-amino-12-(3-amino-3-oxopropyl)-6-carbamoyl-18-(2-carboxyethyl)-9-(3-guanidinopropyl)-1-imino-15-(2-(methylthio)ethyl)-8,11,14,17,20-pentaoxo-2,7,10,13,16,19-hexaazatetracosan-24-oic acid Argireline
Identifiers
CAS Number	616204-22-9 N
ChemSpider	9403386 Y
Jmol 3D model	Interactive image Interactive image
PubChem	11228338
UNII	L4EL31FWIL Y
InChI InChI=1S/C34H60N14O12S/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42)/t18-,19-,20-,21-,22-,23-/m0/s1 Y Key: RJZNPROJTJSYLC-LLINQDLYSA-N Y
SMILES CSCC[C@H]([nH]:c(:[o])[C@H](CCc(:[o]):[oH])[nH]:c(:[o])[C@H](CCc(:[o]):[oH])[nH]:c(C):[o])c(:[o]):[nH][C@@H](CCc(:[nH2]):[o])c(:[o]):[nH][C@@H](CCC[nH]:c(:[nH]):[nH2])c(:[o]):[nH][C@@H](CCC[nH]:c(:[nH]):[nH2])c(:[nH2]):[o] CSCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Properties
Chemical formula	C34H60N14O12S
Molar mass	889.00 g·mol−1
Related compounds
Related compounds	Gusperimus Stearamidopropyl dimethylamine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Acetyl hexapeptide-3 is a synthetic anti-wrinkle cosmetics ingredient. It is a peptide which is a fragment of SNAP-25, a substrate of Botulinum toxin (Botox). Acetyl hexapeptide-3 is marketed as Argireline by the Barcelona-based research laboratory Lipotec.

Overview and common uses

Argireline is used in attempts to decrease the visible effects of aging by reducing the deep wrinkles and lines that occur around the forehead and eyes.

Chemically, when applied as a solution to specific areas of the face, Argireline inhibits the reactions that cause muscles to move or contract – for example when forming facial expressions such as smiling or frowning.

Cosmetic studies

Both in vitro (outside a living organism) and in vivo (using a living organism) tests have been carried out on Argireline, but double-blind clinical trials results have not been published.

Safety research

Argireline has been developed relatively recently and therefore reports on its long-term use have not yet been produced.

Chemistry

Argireline is the hexapeptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂.