Advantame

Advantame

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Names
IUPAC name (3S)-3-[3-(3-Hydroxy-4-methoxyphenyl)propylamino]-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
Systematic IUPAC name N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-α-L-aspartyl]-L-phenylalanine 1-methyl ester
Identifiers
CAS Number	714229-20-6 monohydrate 245650-17-3 anhydrous
ChemSpider	8564873
Jmol 3D model	Interactive image
PubChem	10389431
InChI InChI=1S/C24H30N2O7/c1-32-21-11-10-17(14-20(21)27)9-6-12-25-18(15-22(28)29)23(30)26-19(24(31)33-2)13-16-7-4-3-5-8-16/h3-5,7-8,10-11,14,18-19,25,27H,6,9,12-13,15H2,1-2H3,(H,26,30)(H,28,29)/t18-,19-/m0/s1 Key: YTKBWWKAVMSYHE-OALUTQOASA-N InChI=1/C24H30N2O7/c1-32-21-11-10-17(14-20(21)27)9-6-12-25-18(15-22(28)29)23(30)26-19(24(31)33-2)13-16-7-4-3-5-8-16/h3-5,7-8,10-11,14,18-19,25,27H,6,9,12-13,15H2,1-2H3,(H,26,30)(H,28,29)/t18-,19-/m0/s1 Key: YTKBWWKAVMSYHE-OALUTQOABU
SMILES COC1=C(C=C(C=C1)CCCN[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)OC)O
Properties
Chemical formula	C24H30N2O7
Molar mass	458.51 g·mol−1
Appearance	white to yellow powder
Melting point	99.3–101.5 °C (210.7–214.7 °F; 372.4–374.6 K)
Solubility in water	Slightly soluble
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Advantame is a non-caloric sweetener from Japan's Ajinomoto Co. The U.S. Food and Drug Administration has approved advantame for general use in foods and beverages except meat and poultry as a food additive. It is synthesized from isovanillin and aspartame.

Advantame is classified as generally recognized as safe (GRAS) by the Flavor and Extract Manufacturers Association for use in dairy, frozen desserts, beverages, and chewing gum (FEMA #: 4716).

Animal studies have found no evidence for carcinogenicity or developmental toxicity.