Arterolane

Arterolane
	File:Arterolane.png
Systematic (IUPAC) name
	[(N-(2-amino-2-methylpropyl)-2-cis-dispiro(adamantane-2,3'-[1,2,4]trioxolane-5',1"-cyclohexan)-4"-yl]acetamide
Clinical data
Routes of; administration	oral
Identifiers
CAS Number	664338-39-0
ATC code	none
PubChem	CID: 10475633
ChemSpider	25069705
UNII	3N1TN351VB
Chemical data
Formula	C22H36N2O4
Molecular mass	392.531 g/mol
	SMILES C2C1CC5CC2CC(C5)C1(O3)OOC3(CC4)CCC4CC(=O)NCC(C)(C)N ;
	InChI InChI=1S/C22H36N2O4/c1-20(2,23)13-24-19(25)12-14-3-5-21(6-4-14)26-22(28-27-21)17-8-15-7-16(10-17)11-18(22)9-15/h14-18H,3-13,23H2,1-2H3,(H,24,25)/t14-,15-,16+,17-,18+,21+,22- ; Key:VXYZBLXGCYNIHP-SSPKTAKCSA-N ;
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Arterolane, also known as OZ277 or RBx 11160, is a substance being tested for antimalarial activity^[1] by Ranbaxy Laboratories.^[2] It was discovered by US and European scientists who were coordinated by the Medicines for Malaria Venture (MMV).^[3] Its molecular structure is uncommon for pharmacological compounds in that it has both an ozonide (trioxolane) group and an adamantane substituent.^[4]

Phase III clinical trials of arterolane, in combination with piperaquine, began in India in 2009.^[5] When clinical trial results were disappointing, the MMV withdrew support^[2] and Ranbaxy continued developing the drug combination on its own.

References

↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ ^2.0 ^2.1 Blow to Ranbaxy drug research plans at LiveMint.com, Sep 21 2007
↑ Lua error in package.lua at line 80: module 'strict' not found.
↑ In the Pipeline: "Ozonides As Drugs: What Will They Think Of Next?", by Derek Lowe; published November 23, 2009; retrieved November 17, 2015; at Sciencemag.org
↑ Indian company starts Phase III trials of synthetic artemisinin, May 4 2009, at the WorldWide Antimalarial Resistance Network^{[dead link]}

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

[1] Lua error in package.lua at line 80: module 'strict' not found.

[livemint-2] 2.0 ^2.1 Blow to Ranbaxy drug research plans at LiveMint.com, Sep 21 2007

[3] Lua error in package.lua at line 80: module 'strict' not found.

[4] In the Pipeline: "Ozonides As Drugs: What Will They Think Of Next?", by Derek Lowe; published November 23, 2009; retrieved November 17, 2015; at Sciencemag.org

[5] Indian company starts Phase III trials of synthetic artemisinin, May 4 2009, at the WorldWide Antimalarial Resistance Network^{[dead link]}

[1]

[2]

[3]

[4]

[5]

Arterolane

References

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Systematic (IUPAC) name
File:Arterolane.png
[(N-(2-amino-2-methylpropyl)-2-cis-dispiro(adamantane-2,3'-[1,2,4]trioxolane-5',1"-cyclohexan)-4"-yl]acetamide
Clinical data
Routes of administration	oral
Identifiers
CAS Number	664338-39-0^Y
ATC code	none
PubChem	CID: 10475633
ChemSpider	25069705^Y
UNII	3N1TN351VB^Y
Chemical data
Formula	C₂₂H₃₆N₂O₄
Molecular mass	392.531 g/mol
SMILES C2C1CC5CC2CC(C5)C1(O3)OOC3(CC4)CCC4CC(=O)NCC(C)(C)N
InChI InChI=1S/C22H36N2O4/c1-20(2,23)13-24-19(25)12-14-3-5-21(6-4-14)26-22(28-27-21)17-8-15-7-16(10-17)11-18(22)9-15/h14-18H,3-13,23H2,1-2H3,(H,24,25)/t14-,15-,16+,17-,18+,21+,22-^Y Key:VXYZBLXGCYNIHP-SSPKTAKCSA-N^Y

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