CETN1

Centrin, EF-hand protein, 1
250px PDB rendering based on 1m39.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1m39, 2a4j
Identifiers
Symbols	CETN1 ; CEN1; CETN
External IDs	OMIM: 603187 MGI: 1347086 HomoloGene: 105668 GeneCards: CETN1 Gene
Gene ontology Molecular function • calcium ion binding • protein binding • microtubule binding • G-protein beta/gamma-subunit complex binding • heterotrimeric G-protein binding Cellular component • spindle pole • centrosome • centriole • photoreceptor connecting cilium Biological process • mitotic nuclear division • cellular response to heat • cell division Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CETN1 207209 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1068	26369
Ensembl	ENSG00000177143	ENSMUSG00000050996
UniProt	Q12798	P41209
RefSeq (mRNA)	NM_004066	NM_007593
RefSeq (protein)	NP_004057	NP_031619
Location (UCSC)	Chr 18: 0.58 – 0.58 Mb	Chr 18: 9.62 – 9.62 Mb
PubMed search	[1]	[2]

Centrin-1 is a protein that in humans is encoded by the CETN1 gene. It belongs to the centrin family of proteins.

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.