COX7C

Cytochrome c oxidase subunit VIIc
Identifiers
Symbol	COX7C
External IDs	OMIM: 603774 MGI: 103226 HomoloGene: 135674 GeneCards: COX7C Gene
EC number	1.9.3.1
Gene ontology Molecular function • cytochrome-c oxidase activity Cellular component • mitochondrion • mitochondrial inner membrane • integral component of membrane Biological process • generation of precursor metabolites and energy • transcription initiation from RNA polymerase II promoter • gene expression • respiratory electron transport chain • cellular metabolic process • small molecule metabolic process • hydrogen ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE COX7C 201134 x at tn.png
File:PBB GE COX7C 217491 x at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1350	12867
Ensembl	ENSG00000127184	ENSMUSG00000017778
UniProt	P15954	P17665
RefSeq (mRNA)	NM_001867	NM_007749
RefSeq (protein)	NP_001858	NP_031775
Location (UCSC)	Chr 5: 86.62 – 86.62 Mb	Chr 13: 86.04 – 86.05 Mb
PubMed search	[1]	[2]

Cytochrome c oxidase subunit 7C, mitochondrial is an enzyme that in humans is encoded by the COX7C gene.

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13.