Chloroxine

Clinical data
Trade names	Capitrol
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Legal status	US: ℞-only
Identifiers
ATC code	none
PubChem	CID: 2722
ChemSpider	2621
UNII	2I8BD50I8B
ChEMBL	CHEMBL1200596
Synonyms	cloroxinum, kloroxin, chlorquinol, dichlorchinolinolum, halquinol(s)
Chemical data
Formula	C9H5Cl2NO
Molecular mass	214 g/mol
SMILES Clc1c(O)c2ncccc2c(Cl)c1
InChI InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H Key:WDFKMLRRRCGAKS-UHFFFAOYSA-N

Chloroxine (trade name Capitrol; Kloroxin, Dichlorchinolinol, chlorquinol, halquinol(s)); Latin cloroxinum, dichlorchinolinolum) is an antibacterial drug. Oral formulations (under trade name such as Endiaron) are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis., as used in shampoos (Capitrol) and dermal creams like (Valpeda, Triaderm).

Mechanism of action

Chloroxine has bacteriostatic, fungistatic, and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella, and Trichomonads.

Adverse effects

Rarely occurs, but may cause nausea and vomiting associated with oral administration. It may also cause skin irritation.

Pregnancy and lactation

The FDA lists chloroxine in Pregnancy Category C (risk cannot be ruled out) because no pregnancy studies on the medication have been performed with animals or humans. For this reason, use of chloroxine oral or topical during pregnancy or when breast-feeding is not recommended.

History

Chloroxine was first prepared in 1888 by A. Hebebrand.