Cytochrome b5 reductase

Cytochrome-b₅ reductase (also known as methemoglobin reductase) is a NADH-dependent enzyme that converts methemoglobin to hemoglobin. It contains FAD and catalyzes the reaction:

NADH + H⁺ + 2 ferricytochrome b₅ = NAD⁺ + 2 ferrocytochrome b₅

The following four human genes encode cytochrome-b₅ reductases:

• CYB5R1
• CYB5R2
• CYB5R3
• CYB5R4

See also

• Cytochrome b5
• Methemoglobinemia
• Reductase

External links

• Cytochrome-B(5) Reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
• PDB: 1IB0​ - crystal structure of rat CBR complexed with NAD
• PDB: 1NDH​ - crystal structure of pig liver CBR
• PDB: 1UMK​ - crystal structure of human erythrocyte CBR
• IPR001834 - InterPro entry for CBR