Delta endotoxin
delta endotoxin, N-terminal domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
crystal structure of the insecticidal bacterial del endotoxin Cry3Bb1 bacillus thuringiensis
|
|||||||||
Identifiers | |||||||||
Symbol | Endotoxin_N | ||||||||
Pfam | PF03945 | ||||||||
InterPro | IPR005639 | ||||||||
SCOP | 1dlc | ||||||||
SUPERFAMILY | 1dlc | ||||||||
TCDB | 1.C.2 | ||||||||
|
delta endotoxin | |||||||||
---|---|---|---|---|---|---|---|---|---|
Structure of insecticidal delta-endotoxin from Bacillus thuringiensis.[1]
|
|||||||||
Identifiers | |||||||||
Symbol | Endotoxin_M | ||||||||
Pfam | PF00555 | ||||||||
InterPro | IPR015790 | ||||||||
SCOP | 1dlc | ||||||||
SUPERFAMILY | 1dlc | ||||||||
TCDB | 1.C.2 | ||||||||
OPM superfamily | 95 | ||||||||
OPM protein | 1w99 | ||||||||
|
Bacillus thuringiensis delta-Endotoxin, middle domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
insecticidal crystal protein cry2aa
|
|||||||||
Identifiers | |||||||||
Symbol | Endotoxin_mid | ||||||||
Pfam | PF09131 | ||||||||
InterPro | IPR015214 | ||||||||
SCOP | 1i5p | ||||||||
SUPERFAMILY | 1i5p | ||||||||
|
delta endotoxin | |||||||||
---|---|---|---|---|---|---|---|---|---|
insecticidal crystal protein cry2aa
|
|||||||||
Identifiers | |||||||||
Symbol | Endotoxin_C | ||||||||
Pfam | PF03944 | ||||||||
Pfam clan | CL0202 | ||||||||
InterPro | IPR005638 | ||||||||
SCOP | 1dlc | ||||||||
SUPERFAMILY | 1dlc | ||||||||
TCDB | 1.C.2 | ||||||||
CDD | cd04085 | ||||||||
|
Delta endotoxins (δ-endotoxins, also called Cry and Cyt toxins) are pore-forming toxins produced by Bacillus thuringiensis species of bacteria. They are useful for their insecticidal action.
During spore formation the bacteria produce crystals of this protein. When an insect ingests these proteins, they are activated by proteolytic cleavage. The N-terminus is cleaved in all of the proteins and a C-terminal extension is cleaved in some members. Once activated, the endotoxin binds to the gut epithelium and causes cell lysis by the formation of cation-selective channels, which leads to death. The activated region of the delta toxin is composed of three distinct structural domains: an N-terminal helical bundle domain (IPR005639) involved in membrane insertion and pore formation; a beta-sheet central domain involved in receptor binding; and a C-terminal beta-sandwich domain (IPR005638) that interacts with the N-terminal domain to form a channel.[2][3][4][5]
References
<templatestyles src="Reflist/styles.css" />
Cite error: Invalid <references>
tag; parameter "group" is allowed only.
<references />
, or <references group="..." />
Further reading
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
This article incorporates text from the public domain Pfam and InterPro IPR015790
<templatestyles src="Asbox/styles.css"></templatestyles>
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.