ER retention
ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins.
Their localization to the ER often depends on certain sequences of amino acids located at the N-terminal or C-terminal. The classical ER retention signal is the C-terminal KDEL sequence for lumen bound proteins and KKXX for transmembrane localization. These signals allow for retrieval from the Golgi apparatus, effectively maintaining the protein in the ER.[1] Other mechanisms for ER retention are being studied but are not as well characterized as signal retention.
ER retention receptors
References
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