FABP7
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.[1]
Function
The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.[1]
FABP7 is expressed, during development, in radial glia by the activation of Notch receptors.[2] Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation.[3]
According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.[4]
Role in pathology
FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.[5]
As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia,[6] with one, that tested for only one SNP, showing negative[7] and another, with seven SNPs,[8] a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.
References
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External links
- Schizophrenia, Startled Response & Fabp7: Future Dietary Changes for At-Risk Mothers? Schizophrenia Daily News Blog, 2007-11-07
- Gross L (2007) A Candidate Gene for a Biological Marker of Schizophrenia in Mice" PLoS Biol 5(11) e320 doi:10.1371/journal.pbio.0050320 - a synopsis for the general audience.
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- ↑ Gene Overview of All Published Schizophrenia-Association Studies for FABP7 - SZGene database at Schizophrenia Research Forum website.
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