FBXO32

F-box protein 32
Identifiers
Symbols	FBXO32 ; Fbx32; MAFbx
External IDs	OMIM: 606604 MGI: 1914981 HomoloGene: 12182 GeneCards: FBXO32 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleolus • Z disc Biological process • response to denervation involved in regulation of muscle adaptation • protein ubiquitination • cellular response to dexamethasone stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114907	67731
Ensembl	ENSG00000156804	ENSMUSG00000022358
UniProt	Q969P5	Q9CPU7
RefSeq (mRNA)	NM_001242463	NM_026346
RefSeq (protein)	NP_001229392	NP_080622
Location (UCSC)	Chr 8: 123.5 – 123.54 Mb	Chr 15: 58.18 – 58.21 Mb
PubMed search	[1]	[2]

F-box only protein 32 is a protein that in humans is encoded by the FBXO32 gene.

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes.

Interactions

FBXO32 has been shown to interact with EIF3A.