FGI-106

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FGI-106
File:FGI-106 structure.png
Systematic (IUPAC) name
1-N,7-N-bis[3-(dimethylamino)propyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine
Clinical data
Legal status
  • Investigational New Drug
Identifiers
CAS Number 501081-38-5 YesY
PubChem CID: 432342
ChemSpider 382357
Chemical data
Formula C28H38N6
Molecular mass 458.640
  • CN(C)CCCNc(c2ccc14)cc(C)nc2c1ccc3c4nc(C)cc3NCCCN(C)C
  • InChI=1S/C28H38N6/c1-19-17-25(29-13-7-15-33(3)4)23-11-10-22-21(27(23)31-19)9-12-24-26(18-20(2)32-28(22)24)30-14-8-16-34(5)6/h9-12,17-18H,7-8,13-16H2,1-6H3,(H,29,31)(H,30,32)
  • Key:WJUPENLNVUCETH-UHFFFAOYSA-N

FGI-106 is a broad-spectrum antiviral drug developed as a potential treatment for enveloped RNA viruses, in particular viral hemorrhagic fevers from the bunyavirus, flavivirus and filovirus families. It acts as an inhibitor which blocks viral entry into host cells. In animal tests FGI-106 shows both prophylactic and curative action against a range of deadly viruses for which few existing treatments are available, including the bunyaviruses Hantavirus, Rift Valley fever virus and Crimean-Congo hemorrhagic fever virus, the flavivirus Dengue virus, and the filoviruses Ebola virus and Marburg virus.[1][2][3][4]

See also

References

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