FGR (gene)
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.[1][2]
Function
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]
Discovery
The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.[3]
Interactions
FGR (gene) has been shown to interact with Wiskott-Aldrich syndrome protein.[4][5][6]
References
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