Folin's reagent

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Folin's reagent
Skeletal formula of Folin's reagent
Space-filling model of the Folin's reagent molecule
Names
IUPAC name
Sodium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
Identifiers
521-24-4
ChemSpider 10190
EC Number 208-308-9
Jmol 3D model Interactive image
PubChem 10636
  • InChI=1S/C10H6O5S.Na/c11-8-5-9(16(13,14)15)6-3-1-2-4-7(6)10(8)12;/h1-5H,(H,13,14,15);/q;+1/p-1
    Key: UBLXEEBHYISRFM-UHFFFAOYSA-M
  • InChI=1/C10H6O5S.Na/c11-8-5-9(16(13,14)15)6-3-1-2-4-7(6)10(8)12;/h1-5H,(H,13,14,15);/q;+1/p-1
    Key: UBLXEEBHYISRFM-REWHXWOFAQ
  • C1=CC=C2C(=C1)C(=CC(=O)C2=O)S(=O)(=O)[O-].[Na+]
Properties
C10H5NaO5S
Molar mass 260.20 g/mol
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Folin's reagent or sodium 1,2-naphthoquinone-4-sulfonate is a chemical reagent used to measure levels of amines and amino acids.[1] The reagent produces a bright red color in alkaline solutions and is also fluorescent.[2]

This should not be confused with Folin-Ciocalteu reagent, which is a mixture of sodium tungstate and sodium molybdate that is used to detect phenolic compounds.

The Folin reagent can be used with an acidic secondary reagent to distinguish MDMA and related compounds from PMMA and related compounds.[3]

Substance Reaction
MDMA Pink[3]
MDE No Reaction[3]
MDA Yellow[3]
BZP Orange to red[3]
TFMPP Pinkish red[3]
Methylone No reaction[3]
Methamphetamine Pink[3]
Amphetamine Light orange[3]
PMA Light Yellow[3]
PMMA Light orange[3]
Ketamine No reaction[3]
Mescaline No reaction[3]
Cocaine No reaction[3]
Aspirin No reaction[3]
Sugar No reaction[3]

See also

References

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  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 Lua error in package.lua at line 80: module 'strict' not found.
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