GSTP1

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene.[1][2]

Function

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.[3]

Interactions

GSTP1 has been shown to interact with Fanconi anemia, complementation group C[4][5] and MAPK8.[6]

GST-Pi is expressed in many human tissues, particularly in the biliary tree and renal distal convoluted tubules.[7]

Possible drug target

Triple-negative breast cancer cells rely on glutathione-S-transferase Pi1, and inhibitors are being studied.[8]

References

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Further reading

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  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  8. ↑ Triple-negative breast cancer target is found. May 2016
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