GTF3C5

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). General transcription factor 3C polypeptide 5 is a protein that in humans is encoded by the GTF3C5 gene.[1][2]

Model organisms

Model organisms have been used in the study of GTF3C5 function. A conditional knockout mouse line, called Gtf3c5tm2a(KOMP)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty four tests were carried out on mutant mice and two significant abnormalities were observed.[5] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.[5]

Interactions

GTF3C5 has been shown to interact with GTF3C2[1] and GTF3C4.[13]

References

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Further reading

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  6. Mouse Resources Portal, Wellcome Trust Sanger Institute.
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