Glucose 1-dehydrogenase (NAD+)

In enzymology, a glucose 1-dehydrogenase (NAD⁺) (EC 1.1.1.118) is an enzyme that catalyzes the chemical reaction

D-glucose + NAD⁺ $\rightleftharpoons$ D-glucono-1,5-lactone + NADH + H⁺

Thus, the two substrates of this enzyme are D-glucose and NAD⁺, whereas its 3 products are D-glucono-1,5-lactone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-glucose:NAD⁺ 1-oxidoreductase. Other names in common use include D-glucose:NAD⁺ oxidoreductase, D-aldohexose dehydrogenase, and glucose 1-dehydrogenase (NAD⁺).

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2DTD, 2DTE, and 2DTX.