H-89

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For the Heath H-89 microcomputer, see Zenith Z-89.

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H-89
200px
Names
IUPAC name
N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide
Identifiers
127243-85-0 YesY
ChEMBL ChEMBL104264 N
ChemSpider 395827 N
5983
Jmol 3D model Interactive image
PubChem 449241
  • InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+ N
    Key: ZKZXNDJNWUTGDK-NSCUHMNNSA-N N
  • InChI=1/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
    Key: ZKZXNDJNWUTGDK-NSCUHMNNBL
  • c1cc2cnccc2c(c1)S(=O)(=O)NCCNC/C=C/c3ccc(cc3)Br
Properties
C20H20BrN3O2S
Molar mass 446.36 g·mol−1
Soluble to 25 mM in Water
Solubility up to 100 mM DMSO
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

H-89 is a Protein kinase A inhibitor that also inhibits several other kinases (IC50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b).[1][2] H-89 blocks PKA actions through competitive inhibition of the adenosine triphosphate (ATP) site on the PKA catalytic subunit.[3]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Andrew J. Murray. 2008. Pharmacological PKA Inhibition: All May Not Be What It Seems. Science Signaling 1 (22) re4


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