Histone deacetylase 2
From Infogalactic: the planetary knowledge core
(Redirected from HDAC2)
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene.[1]
Function
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.[2]
Interactions
Histone deacetylase 2 has been shown to interact with:
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- Ataxia telangiectasia and Rad3 related,[3]
- BUB3,[4]
- CDC20,[4]
- CDH1,[4]
- CHD3,[5][6][7]
- CHD4,[3][5][6]
- DNMT1,[8]
- EED,[9]
- EZH2[9] and
- FKBP3,[10]
- GATA4,[11]
- GTF2I,[5][12]
- HDAC10,[13]
- HDAC1,[5][6][9][13][14][15][16][17][18][19][20][21][22]
- HMG20B,[5][15]
- HSPA4,[16]
- Host cell factor C1,[23]
- MTA1,[5][14][24]
- MTA2,[5][14][20]
- MXD1,[25][26]
- Mad1,[4]
- Methyl-CpG-binding domain protein 2,[20][27][28]
- PHF21A,[5][15][29]
- PPP1R8,[30]
- RBBP4,[5][6][31][32]
- RCOR1,[15][33]
- RELA,[34][35]
- Retinoblastoma protein,[36]
- SAP30,[20][37][38]
- SIN3A,[5][6][25][31][32][39][40]
- SMARCA5,[7]
- SNW1,[41]
- SUV39H1,[42]
- Sp1 transcription factor,[32][43][44]
- Sp3 transcription factor,[43][44]
- TOP2B,[45] and
- YY1.[46][47][48]
See also
References
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<references />, or <references group="..." />Further reading
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External links
- HDAC2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook HDAC2
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