MED12
From Infogalactic: the planetary knowledge core
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human gene found on the X chromosome.[1]
Clinical significance
Mutations in MED12 are responsible for at least two different forms of X-linked dominant mental retardation, Lujan-Fryns syndrome and FG syndrome, as well as instances of prostate cancer.[2]
Mutations in MED12 are associated to uterine leiomyomas [3] and breast fibroepithelial tumors (e.g. fibroadenoma and phyllodes tumors).[4]
Interactions
MED12 has been shown to interact with:
- Calcitriol receptor,[5][6]
- Cyclin-dependent kinase 8[5][7]
- Estrogen receptor alpha,[7]
- Gli3, G9a, PPARGC1A,[8]
- MED26,[9]
- SOX9,[10] and
- Thyroid hormone receptor alpha.[5]
References
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External links
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