MT-TH
| mitochondrially encoded tRNA histidine | |
|---|---|
| Identifiers | |
| Symbol | MT-TH |
| Alt. symbols | MTTH |
| Entrez | 4564 |
| HUGO | 7487 |
| OMIM | 590040 |
| RefSeq | NC_001807 |
| Other data | |
| Locus | Chr. MT [1] |
Mitochondrially encoded tRNA histidine, also known as MT-TH, is a transfer RNA which, in humans, is encoded by the mitochondrial MT-TH gene.[1]
Function
MT-TH is a small 69 nucleotide RNA (human mitochondrial map position 12138-12206) that transfers the amino acid histidine to a growing polypeptide at the ribosomal site of protein synthesis during translation.
Clinical significance
MT-TH is associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).[2][3]
It has also been associated with MERRF syndrome.[2]
References
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