Methionine sulfoximine
| Names | |
|---|---|
| IUPAC name
2-Amino-4-(S-methylsulfonimidoyl)butanoic acid
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| Other names
MSO
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| Identifiers | |
| ChemSpider | 15302 |
| Jmol 3D model | Interactive image |
| PubChem | 16118 |
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| Properties | |
| C5H12N2O3S | |
| Molar mass | 180.22 g·mol−1 |
| Related compounds | |
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Related compounds
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Buthionine sulfoximine Glufosinate |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |
Methionine sulfoximine (MSO) is an irreversible glutamine synthetase inhibitor. It's the sulfoximine derivative of methionine with convulsant effects.[1]
Mechanism of action
MSO is phosphorylated by glutamine synthetase. The resulting product acts as a transition state analog that irreversibly binds to the glutamine synthetase, thereby inhibiting the enzyme.[2]
See also
References
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