Neurogranin
| neurogranin (protein kinase C substrate, RC3) | |
|---|---|
| Identifiers | |
| Symbol | NRGN |
| Entrez | 4900 |
| HUGO | 8000 |
| OMIM | 602350 |
| RefSeq | NM_006176 |
| UniProt | Q92686 |
| Other data | |
| Locus | Chr. 11 q24 |
Neurogranin is a calmodulin-binding protein expressed exclusively in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability. NRGN gene expression is controlled by thyroid hormones.[1] Human neurogranin consists of 78 amino acids.
One study tells of potential link of neurogranin gene to the heightened risk of schizophrenia in males,[2] another study gives evidence of lowered neurogranin immunoreactivity in the brains of people suffering from schizophrenia.[3]
Prior to its identification in the bovine and rat brain in 1991,[4] neurogranin was known as a putative protein kinase C-phosphorylated protein named p17. Human neurogranin was cloned in 1997 and turned out to be 96% identical to the rat protein.[5]
External links
- Neurogranin at the US National Library of Medicine Medical Subject Headings (MeSH)
References
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