PEX14
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Function
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.[2]
Interactions
PEX14 has been shown to interact with
References
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<references />, or <references group="..." />Further reading
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External links
- GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
- OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
- Eukaryotic Linear Motif resource motif class TRG_PEX_1
- Eukaryotic Linear Motif resource motif class TRG_PEX_2
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