Phenprocoumon

Phenprocoumon

File:Phenprocoumon.svg
Systematic (IUPAC) name
(RS)-4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one
Clinical data
Trade names	Marcoumar, Marcumar, Falithrom
AHFS/Drugs.com	International Drug Names
MedlinePlus	a699003
Legal status	℞ (Prescription only)
Pharmacokinetic data
Protein binding	99%
Metabolism	hepatic to inactive metabolites
Biological half-life	5 to 6 days
Identifiers
CAS Number	435-97-2 Y
ATC code	B01AA04 (WHO)
PubChem	CID: 9908
IUPHAR/BPS	6839
DrugBank	DB00946 Y
ChemSpider	10441592 Y
UNII	Q08SIO485D Y
KEGG	D05457 Y
ChEBI	CHEBI:50438 Y
ChEMBL	CHEMBL1465 Y
Chemical data
Formula	C18H16O3
Molecular mass	280.318 g/mol
SMILES OC=1c3ccccc3OC(=O)C=1C(CC)c2ccccc2
InChI InChI=1S/C18H16O3/c1-2-13(12-8-4-3-5-9-12)16-17(19)14-10-6-7-11-15(14)21-18(16)20/h3-11,13,19H,2H2,1H3 Y Key:DQDAYGNAKTZFIW-UHFFFAOYSA-N Y
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Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting oral anticoagulant drug, a derivative of coumarin. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders (thrombosis/pulmonary embolism). It is the standard coumarin used in Germany.

Phenprocoumon is a 4-hydroxycoumarin and inhibits vitamin K epoxide reductase.

External links

• DDB 29943