Remogliflozin etabonate
Lua error in Module:Infobox at line 314: malformed pattern (missing ']'). Remogliflozin etabonate (INN/USAN)[1] is a proposed drug of the gliflozin class for the treatment of type 2 diabetes, investigated by GlaxoSmithKline.[2] Remogliflozin is now being developed by BHV Pharma with Islet Sciences.[3]
Clinical trials
Remogliflozin etabonate (RE) was shown to enhance urinary glucose excretion in rodents and humans. Early studies in diabetics improved plasma glucose levels.[4][5] Remogliflozin etabonate has been studied at doses up to 1000 mg.[6] A pair of 12-week phase 2b randomized clinical trials of diabetics published in 2015, found reductions in glycated hemoglobin and that it was generally well tolerated.[7]
Method of action
Remogliflozin etabonate is a pro-drug of remogliflozin. Remogliflozin inhibits the sodium-glucose transport proteins (SGLT), which are responsible for glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine.[8] Remogliflozin is selective for SGLT2.
See also
References
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- ↑ Statement on a nonproprietory name adopted by the USAN council
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- ↑ Prous Science: Molecule of the Month November 2007[dead link]
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