TM4SF5
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| Transmembrane 4 L six family member 5 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | TM4SF5 | ||||||||||
| External IDs | OMIM: 604657 MGI: 1922854 HomoloGene: 2947 GeneCards: TM4SF5 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE TM4SF5 206242 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 9032 | 75604 | |||||||||
| Ensembl | ENSG00000142484 | ENSMUSG00000018919 | |||||||||
| UniProt | O14894 | Q91XF2 | |||||||||
| RefSeq (mRNA) | NM_003963 | NM_029360 | |||||||||
| RefSeq (protein) | NP_003954 | NP_083636 | |||||||||
| Location (UCSC) | Chr 17: 4.77 – 4.78 Mb |
Chr 11: 70.51 – 70.51 Mb |
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| PubMed search | [1] | [2] | |||||||||
Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.[1][2]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.[2]
References
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