TMUB2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the TMUB2 gene.[1][2][3]
Contents
Gene
TMUB2 maps on the human chromosome 17, at locus 17q21.31.[3] TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right.[4] TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.[5]
Expression
TMUB2 is likely ubiquitously expressed throughout the human body.[6] It has a high expression level that is 2.9 times higher than other human genes.[7][8]
Protein
The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions.[9] These will likely vary in orthologs.
Homology
Paralogs
TMUB1 is the only paralog of TMUB2.[10][11] These proteins share a 38% identity and 51% similarity.[12]
Orthologs
The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.[12]
| Species | Common Name | Accession Number | Sequence Length (aa) | Sequence Identity | Sequence Similarity |
|---|---|---|---|---|---|
| Pan troglodytes | Chimpanzee | XP_003953053.1 | 301 | 100% | 100% |
| Felis Catus | Cat | XP_003997025.1 | 322 | 95% | 95% |
| Mus Musculus | Mouse | AAH29841.2 | 319 | 85% | 88% |
| Alligator Mississippiensus | Alligator | XP_006271613.1 | 306 | 61% | 71% |
| Haliaeetus leucocephalus | Bald Eagle | XP_010559728 | 301 | 59% | 70% |
| Danio rerio | Zebrafish | NP_001005573.1 | 291 | 47% | 60% |
| Acromyrmex echinatior | Ant | XP_011049429.1 | 354 | 23% | 42% |
| Nannochloropsis Gaditana* | Algae | EWM26843.1 | 476 | 41% | 54% |
| Coccidioides immitis RS* | Pathogenic Fungus | XP_001242306.1 | 418 | 38% | 50% |
*Limited Query Coverage
Protein Interactions
In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2.[13][14][15][16] Other proposed interactions include BCL2L13 (BCL2-like 13),[17] SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein),[17] and UBQLN1 (Ubiquilin-1).[17][18][19]
References
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- ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ UCSC Genome Browser: BLAT Search
- ↑ NCBI Gene: TMUB2
- ↑ EST Profile Viewer: Human
- ↑ Aceview: TMUB2
- ↑ NCBI GEO Profiles
- ↑ SDSC Biology Workbench 2.0
- ↑ GeneCards: TMUB2
- ↑ NCBI Gene: TMUB1
- ↑ 12.0 12.1 NCBI BLAST: Basic Local Alignment Search Tool
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- ↑ 17.0 17.1 17.2 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ STRING: Functional Protein Association Networks
- ↑ BioGRID Database
