TOB1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Protein Tob1 is a protein that in humans is encoded by the TOB1 gene.[1][2][3]
Function
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein suppresses cell growth in tissue culture. The protein undergoes phosphorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.[3]
Interactions
TOB1 has been shown to interact with:
References
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External links
- TOB1 human gene location in the UCSC Genome Browser.
- TOB1 human gene details in the UCSC Genome Browser.
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