Template:PBB/3133

Major histocompatibility complex, class I, E
250px PDB rendering based on 1kpr.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1KPR, 1KTL, 1MHE, 2ESV, 3AM8, 3BZE, 3BZF, 3CDG, 3CII
Identifiers
Symbols	HLA-E ; EA1.2; EA2.1; HLA-6.2; MHC; QA1
External IDs	OMIM: 143010 MGI: 95957 HomoloGene: 134018 GeneCards: HLA-E Gene
Gene ontology Molecular function • receptor binding • beta-2-microglobulin binding • MHC class I protein binding • peptide antigen binding • natural killer cell lectin-like receptor binding Cellular component • Golgi membrane • plasma membrane • cell surface • ER to Golgi transport vesicle membrane • phagocytic vesicle membrane • early endosome membrane • MHC class Ib protein complex • MHC class I protein complex • extracellular exosome • integral component of lumenal side of endoplasmic reticulum membrane Biological process • positive regulation of T cell mediated cytotoxicity • adaptive immune response • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of endogenous peptide antigen via MHC class Ib • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • regulation of natural killer cell mediated immunity • positive regulation of natural killer cell mediated immunity • cytokine-mediated signaling pathway • antibacterial humoral response • positive regulation of interleukin-13 production • positive regulation of interleukin-4 production • positive regulation of TRAIL production • positive regulation of tumor necrosis factor production • CD8-positive, alpha-beta T cell activation • protection from natural killer cell mediated cytotoxicity • antigen processing and presentation of exogenous peptide antigen via MHC class I • innate immune response • regulation of immune response • defense response to Gram-positive bacterium • positive regulation of immunoglobulin secretion • interferon-gamma-mediated signaling pathway • type I interferon signaling pathway • positive regulation of CD8-positive, alpha-beta T cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE HLA-E 200904 at tn.png
File:PBB GE HLA-E 200905 x at tn.png
File:PBB GE HLA-E 217456 x at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3133	15040
Ensembl	ENSG00000204592	ENSMUSG00000067212
UniProt	P13747	P06339
RefSeq (mRNA)	NM_005516	NM_010398
RefSeq (protein)	NP_005507	NP_034528
Location (UCSC)	Chr 6: 30.49 – 30.49 Mb	Chr 17: 36.03 – 36.03 Mb
PubMed search	[1]	[2]