Template:PBB/4057

Lactotransferrin
Richardson diagram of recombinant human lactoferrin. Based on PDB: 1b0l​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1B0L, 1BKA, 1CB6, 1DSN, 1EH3, 1FCK, 1H43, 1H44, 1H45, 1HSE, 1L5T, 1LCF, 1LCT, 1LFG, 1LFH, 1LFI, 1LGB, 1N76, 1SQY, 1U62, 1VFD, 1VFE, 1XV4, 1XV7, 1Z6V, 1Z6W, 2BJJ, 2DP4, 2GMC, 2GMD, 2HD4, 2PMS
Identifiers
Symbols	LTF ; GIG12; HEL110; HLF2; LF
External IDs	OMIM: 150210 MGI: 96837 HomoloGene: 1754 GeneCards: LTF Gene
EC number	3.4.21.-
Gene ontology Molecular function • DNA binding • serine-type endopeptidase activity • iron ion binding • protein binding • heparin binding • protein serine/threonine kinase activator activity Cellular component • extracellular region • extracellular space • nucleus • cytoplasm • cell surface • secretory granule • specific granule • protein complex • extracellular exosome • phagocytic vesicle lumen Biological process • ossification • regulation of cytokine production • retina homeostasis • innate immune response in mucosa • transcription, DNA-templated • proteolysis • ion transport • humoral immune response • antibacterial humoral response • antifungal humoral response • negative regulation of lipopolysaccharide-mediated signaling pathway • regulation of tumor necrosis factor production • negative regulation of ATPase activity • iron assimilation by chelation and transport • positive regulation of osteoblast proliferation • positive regulation of toll-like receptor 4 signaling pathway • negative regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation by host of viral process • negative regulation of viral genome replication • positive regulation of osteoblast differentiation • negative regulation of viral process • positive regulation of NF-kappaB transcription factor activity • interaction with host • response to host immune response • bone morphogenesis • positive regulation of protein serine/threonine kinase activity • phagosome maturation • positive regulation of bone mineralization involved in bone maturation • negative regulation of single-species biofilm formation in or on host organism • positive regulation of chondrocyte proliferation • negative regulation of tumor necrosis factor (ligand) superfamily member 11 production • negative regulation of osteoclast development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4057	17002
Ensembl	ENSG00000012223	ENSMUSG00000032496
UniProt	P02788	P08071
RefSeq (mRNA)	NM_001199149	NM_008522
RefSeq (protein)	NP_001186078	NP_032548
Location (UCSC)	Chr 3: 46.44 – 46.49 Mb	Chr 9: 111.02 – 111.04 Mb
PubMed search	[1]	[2]