Template:PBB/4193

MDM2 proto-oncogene, E3 ubiquitin protein ligase
Solution structure of Mdm2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2F1Y, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2RUH, 2VJE, 2VJF, 3EQS, 3G03, 3IUX, 3IWY, 3JZK, 3JZR, 3JZS, 3LBK, 3LBL, 3LNJ, 3LNZ, 3MQS, 3TJ2, 3TPX, 3TU1, 3V3B, 3VBG, 3VZV, 3W69, 4DIJ, 4ERE, 4ERF, 4HBM, 4HFZ, 4HG7, 4JV7, 4JV9, 4JVE, 4JVR, 4JWR, 4MDN, 4MDQ, 4OAS, 4OBA, 4OCC, 4ODE, 4ODF, 4OGN, 4OGT, 4OGV, 4OQ3, 4QO4, 4QOC, 4UMN, 4WT2
Identifiers
Symbols	MDM2 ; ACTFS; HDMX; hdm2
External IDs	OMIM: 164785 MGI: 96952 HomoloGene: 1793 ChEMBL: 5023 GeneCards: MDM2 Gene
Gene ontology Molecular function • p53 binding • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity • enzyme binding • ubiquitin protein ligase binding • identical protein binding • ubiquitin protein ligase activity • scaffold protein binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • cytosol • plasma membrane • nuclear body • endocytic vesicle membrane • protein complex Biological process • negative regulation of transcription from RNA polymerase II promoter • protein complex assembly • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • traversing start control point of mitotic cell cycle • epidermal growth factor receptor signaling pathway • synaptic transmission • positive regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • viral process • protein ubiquitination • peptidyl-lysine modification • protein destabilization • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • protein localization to nucleus • Fc-epsilon receptor signaling pathway • regulation of protein catabolic process • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • negative regulation of apoptotic process • negative regulation of DNA damage response, signal transduction by p53 class mediator • innate immune response • establishment of protein localization • negative regulation of transcription, DNA-templated • positive regulation of mitotic cell cycle • response to antibiotic • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • negative regulation of cell cycle arrest • cellular response to hypoxia • negative regulation of signal transduction by p53 class mediator Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4193	17246
Ensembl	ENSG00000135679	ENSMUSG00000020184
UniProt	Q00987	P23804
RefSeq (mRNA)	NM_001145336	NM_001288586
RefSeq (protein)	NP_001138809	NP_001275515
Location (UCSC)	Chr 12: 68.81 – 68.85 Mb	Chr 10: 117.69 – 117.71 Mb
PubMed search	[1]	[2]

References

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