Template:PBB/7535

Zeta-chain (TCR) associated protein kinase 70kDa
PDB rendering based on 1m61.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1FBV, 1M61, 1U59, 2CBL, 2OQ1, 2OZO, 2Y1N, 3ZNI, 4A4B, 4A4C, 4K2R
Identifiers
Symbols	ZAP70 ; SRK; STCD; STD; TZK; ZAP-70
External IDs	OMIM: 176947 MGI: 99613 HomoloGene: 839 ChEMBL: 2803 GeneCards: ZAP70 Gene
EC number	2.7.10.2
Gene ontology Molecular function • phosphotyrosine binding • protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • receptor binding • protein binding • ATP binding Cellular component • immunological synapse • cytoplasm • cytosol • plasma membrane • cell-cell junction • extrinsic component of cytoplasmic side of plasma membrane • T cell receptor complex • membrane raft Biological process • adaptive immune response • protein phosphorylation • immune response • transmembrane receptor protein tyrosine kinase signaling pathway • peptidyl-tyrosine phosphorylation • cell differentiation • T cell differentiation • intracellular signal transduction • peptidyl-tyrosine autophosphorylation • T cell activation • B cell activation • beta selection • positive thymic T cell selection • negative thymic T cell selection • innate immune response • positive regulation of T cell differentiation • positive regulation of alpha-beta T cell differentiation • positive regulation of alpha-beta T cell proliferation • positive regulation of calcium-mediated signaling • T cell receptor signaling pathway • T cell aggregation • T cell migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7535	22637
Ensembl	ENSG00000115085	ENSMUSG00000026117
UniProt	P43403	P43404
RefSeq (mRNA)	NM_001079	NM_001289612
RefSeq (protein)	NP_001070	NP_001276541
Location (UCSC)	Chr 2: 97.71 – 97.74 Mb	Chr 1: 36.76 – 36.78 Mb
PubMed search	[1]	[2]