UBE2A
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.[1][2]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[2]
Interactions
UBE2A has been shown to interact with RAD18[3][4] and P53.[5]
References
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Further reading
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