Vacuolar interface dermatitis

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Micrograph of a vacuolar interface dermatitis with dermal mucin, as may be seen in lupus. H&E stain.

Vacuolar interface dermatitis (VAC, also known as liquefaction degeneration, vacuolar alteration or hydropic degeneration) is a dermatitis where degenerative changes occur at the dermoepidermal junction, with lymphophatic inflammation at the epidermis and dermis.[1] This change is frequently found in lupus erythematosis, erythema multiforme and lichen sclerosis.

References

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