WY-46824

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WY-46824
200px
Systematic (IUPAC) name
1-[1-(3-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexan-1-ol
Identifiers
PubChem CID: 10314993
ChemSpider 8490458
ChEMBL CHEMBL511347
Chemical data
Formula C19H29ClN2O
Molecular mass 336.89936 g/mol
  • CN1CCN(CC1)CC(C2=CC(=CC=C2)Cl)C3(CCCCC3)O
  • InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3
  • Key:GRUIIAQNNWQJPW-UHFFFAOYSA-N

WY-46824 is a norepinephrine-dopamine reuptake inhibitor that was disclosed by Paige Mahaney, et al. of Wyeth in 2008.[1] The compound actually appears in an article a year earlier in 2007 but is not the main focus of the work.[2] These are the only two citations that can be found for it on PubMed. It has been patented but presumably within the framework of it being an analog of venlafaxine.[3]

It has NET binding of 46 nM, DAT = 58 nM and SERT = 18795 nM. The racemic compound was resolved into its constituent enantiomers.

References

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  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ U.S. Patent 4,826,844
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