Weber's syndrome
Lua error in Module:Infobox at line 235: malformed pattern (missing ']'). Weber's syndrome (superior alternating hemiplegia) is a form of stroke characterized by the presence of an ipsilateral oculomotor nerve palsy and contralateral hemiparesis or hemiplegia.
Cause and presentation
This lesion is usually unilateral and affects several structures in the midbrain including:
| Structure damaged | Effect |
|---|---|
| substantia nigra | contralateral parkinsonism because its dopaminergic projections to the basal ganglia innervate the ipsilateral hemisphere motor field, leading to a movement disorder of the contralateral body. |
| corticospinal fibers | contralateral hemiparesis and typical upper motor neuron findings. It is contralateral because it occurs before the decussation in the medulla. |
| corticobulbar tract | difficulty with contralateral lower facial muscles and hypoglossal nerve functions |
| oculomotor nerve fibers | ipsilateral oculomotor nerve palsy with a drooping eyelid and fixed wide pupil pointed down and out. This leads to diplopia |
It is caused by midbrain infarction as a result of occlusion of the paramedian branches of the posterior cerebral artery or of basilar bifurcation perforating arteries.[1]
History
It carries the name of Sir Hermann David Weber, a German-born physician working in London, who described the condition in 1863.[2][3] It is unrelated to Sturge-Weber syndrome, Klippel-Trenaunay-Weber syndrome or Osler-Weber-Rendu syndrome.
See also
- Alternating hemiplegia of childhood
- Lateral medullary syndrome
- Lateral pontine syndrome
- Medial medullary syndrome
- Medial pontine syndrome
References
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<references />, or <references group="..." />External links
- ↑ Weber's syndrome at GPnotebook
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Weber's syndrome at Who Named It?
