CCL19

Chemokine (C-C motif) ligand 19
Identifiers
Symbols	CCL19 ; CKb11; ELC; MIP-3b; MIP3B; SCYA19
External IDs	OMIM: 602227 MGI: 1346316 HomoloGene: 4569 GeneCards: CCL19 Gene
Gene ontology Molecular function • chemokine activity • CCR7 chemokine receptor binding • CCR10 chemokine receptor binding • chemokine receptor binding • CCR chemokine receptor binding Cellular component • extracellular region • extracellular space • intracellular • cell Biological process • establishment of T cell polarity • immunological synapse formation • dendritic cell chemotaxis • myeloid dendritic cell chemotaxis • monocyte chemotaxis • positive regulation of dendritic cell antigen processing and presentation • cellular calcium ion homeostasis • inflammatory response • immune response • cell communication • G-protein coupled receptor signaling pathway • activation of JUN kinase activity • response to virus • positive regulation of glycoprotein biosynthetic process • T cell costimulation • positive regulation of interleukin-12 production • positive regulation of tumor necrosis factor production • response to prostaglandin E • positive regulation of T cell proliferation • positive regulation of NF-kappaB import into nucleus • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of GTPase activity • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of T-helper 1 cell differentiation • positive regulation of endocytosis • positive regulation of protein kinase activity • positive regulation of JNK cascade • lymphocyte chemotaxis • positive regulation of receptor-mediated endocytosis • cell maturation • positive regulation of interleukin-1 beta secretion • positive regulation of chemotaxis • release of sequestered calcium ion into cytosol • positive regulation of protein kinase B signaling • regulation of cell projection assembly • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • response to nitric oxide • interleukin-12 secretion • positive regulation of neutrophil chemotaxis • mature conventional dendritic cell differentiation • cellular response to virus • negative regulation of leukocyte apoptotic process • positive regulation of cell motility • positive regulation of dendritic cell dendrite assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6363	24047
Ensembl	ENSG00000172724	ENSMUSG00000071005
UniProt	Q99731	O70460
RefSeq (mRNA)	NM_006274	NM_011888
RefSeq (protein)	NP_006265	NP_036018
Location (UCSC)	Chr 9: 34.69 – 34.69 Mb	Chr 4: 42.75 – 42.76 Mb
PubMed search	[1]	[2]

Chemokine (C-C motif) ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene.

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.

Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen. The gene for CCL19 is located on human chromosome 9. This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells, CCR7+ central-memory T-Cells.