Emivirine
From Infogalactic: the planetary knowledge core
200px | |
Names | |
---|---|
IUPAC name
1-(ethoxymethyl)-6-(phenylmethyl)-5-propan-2-ylpyrimidine-2,4-dione
|
|
Identifiers | |
149950-60-7 ![]() |
|
ChEMBL | ChEMBL35033 ![]() |
ChemSpider | 58529 ![]() |
Jmol 3D model | Interactive image |
PubChem | 65013 |
UNII | X87G8IX72O ![]() |
|
|
|
|
Properties | |
C17H22N2O3 | |
Molar mass | 302.36818 g/mol |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
|
![]() ![]() ![]() |
|
Infobox references | |
Emivirine (MKC-442) is a failed experimental agent for the treatment of HIV. It is a non-nucleoside reverse transcriptase inhibitor.[1] While emivirine showed promising antiviral activity in vitro, it failed to show sufficient efficacy in human trials. However it is still notable as an early proof of concept, which led to the discovery of a number of related antiviral drugs.[2]
References
- ↑ https://pubchem.ncbi.nlm.nih.gov/compound/Emivirine
- ↑ Calenbergh SV, Herdewijn P. A heterogeneous collection of novel antiviral pyrimidines. Expert Opinion on Therapeutic Patents 2000; 10(3):289-295. DOI:10.1517/13543776.10.3.289
<templatestyles src="Asbox/styles.css"></templatestyles>
Categories:
- Pages with broken file links
- Articles without KEGG source
- Articles with changed InChI identifier
- Pages using collapsible list with both background and text-align in titlestyle
- Chemical articles using a fixed chemical formula
- Abandoned drugs
- Non-nucleoside reverse transcriptase inhibitors
- Pyrimidinediones
- Antiinfective agent stubs