Ibalizumab

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Ibalizumab
Monoclonal antibody
Type Whole antibody
Source Humanized (from mouse)
Target CD4
Clinical data
Pregnancy
category
  • unknown; not enough clinical trial data yet
Legal status
Routes of
administration		 intravenous (IV) injection
Identifiers
CAS Number 680188-33-4 N
ATC code none
UNII LT369U66CE YesY
KEGG D09575 YesY
NIAID ChemDB 209859
 NYesY (what is this?)  (verify)

Ibalizumab (TMB-355[1] previously known as TNX-355) is a non-immunosuppressive monoclonal antibody that binds CD4, the primary receptor for HIV, and inhibits the viral entry process.[2] It is being investigated as an HIV entry inhibitor[3] with the ability to block both CCR5- and CXCR4-tropic viruses,[4] and is undergoing a Phase II clinical trial with an estimated study completion date in December 2010.[5] Specific Research is also conducted at the Aaron Diamond AIDS Research Center under the direction of David Ho.[6][7]

Results from a previous Phase II of ibalizumab, reported by the original developer Tanox in 2006,[4] showed that persons with HIV who received the drug, in combination with an optimized background regimen (OBR), maintained a considerably greater reduction in viral load and experienced a statistically significant increase in CD4+ cells than did patients given placebo in combination with OBR. Thus, pending results of further trials, it is one of a limited number of viable alternative strategies to contain the virus without recourse to antiretroviral drug cocktails or a vaccine.

Development

Ibalizumab is being developed by TaiMed Biologics but was first developed by Tanox, now part of Genentech. As part of Genentech's takeover of Tanox, the patent for ibalizumab was sold to TaiMed Biologics, a biotech company formed in 2007 with support from the Taiwanese Government through a $20 million investment by the state-owned National Development Fund.[8][9][10]

See also

References

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