Esterified estrogen

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Estrone sulfate, the primary active agent of esterified estrogen products.

Esterified estrogens (EEs) (brand names Amnestrogen, Estratab, Estratest, Evex, Femogen, Menest) are synthetic, plant-based estrogens that are manufactured from soybeans and yams.[1][2] They are used in hormone replacement therapy for menopausal symptoms, female hypogonadism, ovariectomy, and primary ovarian failure and in the treatment of prostate cancer.[3]

EEs consist primarily of sodium estrone sulfate and sodium equilin sulfate, and are very similar to conjugated equine estrogen (CEE) preparations such as Premarin.[2][4][5] However, EEs and CEEs differ in the sources of their contents and in the percentages of their constituents; CEEs consist of approximately 53% sodium estrone sulfate and 25% sodium equilin sulfate, while EEs contain approximately 80% sodium estrone sulfate and 11% sodium equilin sulfate.[4][6][3] EEs and CEEs have been found to produce similar serum levels of estrone and estradiol.[7] One study found that the risk of venous thrombosis may be less with EEs relative to CEEs.[6][2]

Estratest is a combination formulation of 1.25 mg EEs with 2.5 mg methyltestosterone.[8]

See also

References

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