Hydroxydione

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Hydroxydione
Hydroxydione.svg
Systematic (IUPAC) name
(5β)-21-Hydroxypregnane-3,20-dione
Identifiers
CAS Number 303-01-5
ATC code None
PubChem CID: 257630
DrugBank DB08956 N
ChemSpider 226020
Chemical data
Formula C21H32O3
Molecular mass 332.477 g/mol
  • C[C@]12CCC(=O)C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CO)C
  • InChI=1S/C21H32O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h13,15-18,22H,3-12H2,1-2H3/t13-,15+,16+,17+,18-,20+,21+/m1/s1
  • Key:USPYDUPOCUYHQL-VEVMSBRDSA-N

Hydroxydione, as hydroxydione sodium succinate (INN, USAN, BAN) (brand names Viadril, Predion, and Presuren),[1][2][3] is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients.[4] It was introduced in 1957,[3] and was the first neuroactive steroid general anesthetic to be introduced for clinical use, an event which was shortly preceded by the observation in 1954 of the sedative properties of progesterone in mice.[5]

See also

References

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