Doxefazepam
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Systematic (IUPAC) name | |
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9-chloro-6-(2-fluorophenyl)-4-hydroxy
-2-(2-hydroxyethyl)-2,5-diazabicyclo [5.4.0]undeca-5,8,10,12-tetraen-3-one |
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Clinical data | |
Legal status |
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Routes of administration |
Oral |
Pharmacokinetic data | |
Metabolism | Hepatic |
Biological half-life | 3-4 hours[1] |
Excretion | Renal |
Identifiers | |
CAS Number | 40762-15-0 ![]() |
ATC code | N05CD12 (WHO) |
PubChem | CID: 38668 |
ChemSpider | 35431 ![]() |
UNII | verifiedrevid = 457288969 231RV72C8L verifiedrevid = 457288969 ![]() |
KEGG | D07327 ![]() |
ChEMBL | CHEMBL64677 ![]() |
Chemical data | |
Formula | C17H14ClFN2O3 |
Molecular mass | 348.8 |
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Doxefazepam (marketed under brand name Doxans) is a benzodiazepine derivative drug developed by Schiapparelli in the 1970s.[2] It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is used therapeutically as a hypnotic.[3] According to Babbini and colleagues in 1975, this derivative of flurazepam was between 2 and 4 times more potent than the latter while at the same time being half as toxic in laboratory animals.[4] Section 5.5 of the article Doxefazepam in volume 66 of the World Health Organization's (WHO) and International Agency for Research on Cancer's (IARC) IARC Monographs On The Evaluation Of Carcinogenic Risks To Humans, an article describing the carcinogenic/toxic effects of doxefazepam on humans and experimental animals, states that there is "inadequate evidence in humans for the carcinogenicity of doxefazepam" and limited evidence in experimental for the carcinogenicity of doxefazepam," and concluded that the overall evaluation of the substance's carcinogenicity to humans is "not classifiable."[5]
See also
References
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External links
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- ↑ http://www.intox.org/databank/documents/pharm/doxefzpm/iarc796.htm
- ↑ DE Patent 2338058 - BENZODIAZEPINVERBINDUNGEN FUER DIE THERAPIE
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- Pages with reference errors
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- Chemical pages without DrugBank identifier
- Articles containing unverified chemical infoboxes
- Alcohols
- Benzodiazepines
- Chloroarenes
- Fluoroarenes
- GABAA receptor positive allosteric modulators
- Hypnotics
- Lactams
- Sedative stubs