Doxefazepam

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Doxefazepam
Doxefazepam.svg
Doxefazepam3d.png
Systematic (IUPAC) name
9-chloro-6-(2-fluorophenyl)-4-hydroxy
-2-(2-hydroxyethyl)-2,5-diazabicyclo
[5.4.0]undeca-5,8,10,12-tetraen-3-one
Clinical data
Legal status
Routes of
administration
Oral
Pharmacokinetic data
Metabolism Hepatic
Biological half-life 3-4 hours[1]
Excretion Renal
Identifiers
CAS Number 40762-15-0 N
ATC code N05CD12 (WHO)
PubChem CID: 38668
ChemSpider 35431 YesY
UNII verifiedrevid = 457288969 231RV72C8L verifiedrevid = 457288969 N
KEGG D07327 YesY
ChEMBL CHEMBL64677 YesY
Chemical data
Formula C17H14ClFN2O3
Molecular mass 348.8
  • FC1=CC=CC=C1C2=NC(C(N(CCO)C3=C2C=C(C=C3)Cl)=O)O
  • InChI=1S/C17H14ClFN2O3/c18-10-5-6-14-12(9-10)15(11-3-1-2-4-13(11)19)20-16(23)17(24)21(14)7-8-22/h1-6,9,16,22-23H,7-8H2 YesY
  • Key:VOJLELRQLPENHL-UHFFFAOYSA-N YesY
 NYesY (what is this?)

Doxefazepam (marketed under brand name Doxans) is a benzodiazepine derivative drug developed by Schiapparelli in the 1970s.[2] It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is used therapeutically as a hypnotic.[3] According to Babbini and colleagues in 1975, this derivative of flurazepam was between 2 and 4 times more potent than the latter while at the same time being half as toxic in laboratory animals.[4] Section 5.5 of the article Doxefazepam in volume 66 of the World Health Organization's (WHO) and International Agency for Research on Cancer's (IARC) IARC Monographs On The Evaluation Of Carcinogenic Risks To Humans, an article describing the carcinogenic/toxic effects of doxefazepam on humans and experimental animals, states that there is "inadequate evidence in humans for the carcinogenicity of doxefazepam" and limited evidence in experimental for the carcinogenicity of doxefazepam," and concluded that the overall evaluation of the substance's carcinogenicity to humans is "not classifiable."[5]

See also

References

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External links

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  1. http://www.intox.org/databank/documents/pharm/doxefzpm/iarc796.htm
  2. DE Patent 2338058 - BENZODIAZEPINVERBINDUNGEN FUER DIE THERAPIE
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