SLC34A3

Solute carrier family 34 (type II sodium/phosphate cotransporter), member 3
Identifiers
Symbols	SLC34A3 ; HHRH; NPTIIc
External IDs	OMIM: 609826 MGI: 2159410 HomoloGene: 15444 GeneCards: SLC34A3 Gene
Gene ontology Molecular function • sodium:phosphate symporter activity • sodium-dependent phosphate transmembrane transporter activity Cellular component • plasma membrane • integral component of membrane • apical plasma membrane • brush border membrane Biological process • ion transport • sodium ion transport • phosphate ion transport • cellular phosphate ion homeostasis • phosphate ion transmembrane transport • sodium ion transmembrane transport • sodium-dependent phosphate transport • transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	142680	142681
Ensembl	ENSG00000198569	ENSMUSG00000006469
UniProt	Q8N130	Q80SU6
RefSeq (mRNA)	NM_001177316	NM_080854
RefSeq (protein)	NP_001170787	NP_543130
Location (UCSC)	Chr 9: 137.23 – 137.24 Mb	Chr 2: 25.23 – 25.23 Mb
PubMed search	[1]	[2]

Sodium-dependent phosphate transport protein 2C is a protein that in humans is encoded by the SLC34A3 gene.

Function

SLC34A3 contributes to the maintenance of inorganic phosphate concentration at the kidney.

Interactions

SLC34A3 has been shown to interact with PDZK1.

Clinical Correlation

A mutation in the SLC34A3 gene has been known to cause the autosomal recessive condition hereditary hypophophatemic rickets with hypercalciuria. This gene is correlated closely with SLC34A1, an analogue sodium phosphate cotransporter protein. Symptoms include renal phosphate wasting in addition to increase levels of 1,25-dihydroxyvitamin D (yields the hypercalcuria).

See also

• SLC34A3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.